244 Retinol and Vitreoscilla filiformis extract, a new synergic complex for anti-ageing skin care benefits

For the first time, retinol has been associated with Vitreoscilla filiformis extract (a probiotic fraction regenerative properties). The efficacy of this new combination was assessed in vitro and confirmed clinical trials. Normal human keratinocytes were treated or not Retinol (0.1 μM), (1.4 x 10-4%) their for 24 hours. Gene expression then evaluated by RT-qPCR. In addition, trials performed to evaluate benefits mixt ingredients (0.25% 1% respectively) a cream on Caucasian Asian women from 20 65 years old using Dermal torque meter, Transepidermal water loss chloride dansyl. Then studies have conducted wrinkles skin homogeneity. inhibited transcript involved differentiation (CALM5, CASP14, KRT10, SPRR1A, SPRR1B, TGM1) while stimulating others linked proliferation (KRT19) innate immunity (S100A7, DEFB4A). potentiates effect amplifying, synergic way additive way, transcripts epidermal renewal (HAS3, MMP3, KRT19 expression). also able reverse some negative effects increasing FLG, LOR, CDSN EPVL. formula containing combo shown an improvement reinforcing barrier function as predicted our study. original decreases visibility, dark spot, improved tone evenness, smoothness improve firmness. act retinoid-multiplier improving reversing inhibitory retinoids. At end, improves parameters decreased during aging decrease signs.